Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial

Protective effect of selenium on cisplatin induced nephrotoxicity: A double-blind controlled randomized clinical trial

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Background: Renal injury is common following cisplatin infusion.Some agents have been used to attenuate cisplatin nephrotoxicity.However, except hydration, none of them has been proved to be effective.Objective: In this study selenium as an antioxidant supplement was tested on cisplatin induced renal injury.Patients and Methods: 122 click here cancerous patients (85 male and 37 female; age range of 14 to 82 years old) were enrolled to receive chemotherapy regimens consisting cisplatin.

They were allocated into two groups using a random number list.Investigators, patients and analyzers all, were blinded in allocation by using sealed opaque envelopes.Intervention group received a single 400 mcg selenium tablet and patients in control group took a placebo tablet which was similar with selenium preparation in color, natio celebrate eyeshadow palette weight, shape and taste.Primary end points were an increase in plasma creatinine above 1.5 mg/dl in men and 1.

4mg/dl in women, or increase of plasma creatinine more than 50% from baseline or urine flow rate less than 0.5 ml/kg/h.Creatinine level was measured initially and on the 5th day after cisplatin therapy.Results: There was no difference in cumulative dose of cisplatin between the groups (p=0.54).

There were not evidences of acute renal failure (ARF) in cases.While, among placebo group, 7 patients had criteria of acute kidney injury.Conclusions: selenium could probably prevent cisplatin-induced acute kidney injury, when it is added to hydration therapy in cancerous patients.